Almost 20 hours into it, haven't even finished main questline yet. The customization for everything will be the death of me, kinda wish the interface was smoother at times but looting bodies just by hovering over is a really nice feature. Had a few jumpscare moments and plenty of explosions, dialogue was awkward occasionally but generally passable. My only other real complaint would be a feeling that quest progression and enemy combat strength is mismatched at times, but that might just be me.
There were also a few bugs, nothing too major that couldn't be fixed by reloading the previous save, but it is annoying when you're trying to talk to a quest related NPC when they're randomly chilling on an unreachable rooftop. I ended up having to build a staircase just to get up there. Dogmeat also just straight up started floating away this one time, that was a little weird too.
Getting crafting resources can be a pain at times but it makes the completed construction more fulfilling I guess.